The upcoming Serie A match between Sassuolo and Genoa on November 3, 2025, at Mapei Stadium features two teams with contrasting recent forms. Sassuolo, currently 11th in the league with 13 points from nine matches, has shown resilience with three wins and one draw in their last five games, including a recent 2-1 victory over Cagliari. Their strong home record and attacking options, notably Andrea Pinamonti and Armand Lauriente, give them an edge. Conversely, Genoa, sitting at the bottom of the table with only three points and no wins in nine league games, continues to struggle offensively, having scored just four goals all season. Their poor run includes six losses and three draws, with recent defeats at home to Cremonense and away to Lazio. Head-to-head history indicates a close rivalry, with recent results favoring Genoa, but Sassuolo's current form suggests they are favorites. Key players to watch include Pinamonti versus Genoa's defender Vásquez and midfield battles involving Thorstvedt and Masini. Injuries may impact team lineups, with Sassuolo missing Domenico Berardi and Daniel Boloca, while Genoa faces several doubts. The prediction favors Sassuolo to secure a 2-1 victory, leveraging their recent form and home advantage, with betting tips supporting a win, over 2.5 goals, and both teams scoring.