Gonzaga, ranked No. 11, is set to face San Francisco at the Chase Center on Wednesday, aiming to extend its winning streak to 35 games against the Dons. The Bulldogs, with a 25-2 record and 13-1 in the West Coast Conference, are coming off a quick turnaround after a recent road game in Spokane, where they narrowly escaped with a 68-66 victory. The upcoming game is critical for Gonzaga to secure the No. 1 seed in the conference tournament and potentially claim the regular-season championship, especially with remaining games against Pacific and Portland. Gonzaga coach Mark Few highlighted the toughness of USF, emphasizing the importance of rest and preparation. The Dons, with a 15-13 record, have struggled recently, losing three straight before a win over San Diego. They may be without key player Tyrone Riley IV due to injury, which could impact their rebounding and scoring, especially against Ike, who has been a dominant force lately. The game will be played in an NBA-sized arena, contrasting with the usual college setting, and betting odds favor Gonzaga by 14.5 points, with predictions favoring Gonzaga to win 81-69. The game will feature a high pace, with the over/under set at 148.5, and betting experts suggest the over as a value play due to recent scoring trends. Gonzaga's offensive efficiency and USF's three-point shooting will be key factors in the outcome, with the Dons needing to contain Gonzaga's transition and second-chance points.