Duke University and Michigan State University are set to face off in a highly anticipated top-10 college basketball game on December 6, 2025. Duke, ranked No. 4, remains undefeated at 9-0 and recently narrowly defeated Florida Gators, led by freshman Cameron Boozer, who averages 23.6 points per game. Michigan State, ranked No. 7, boasts an 8-0 record, with notable wins against Arkansas, Kentucky, and North Carolina. The Spartans are led by Jeremy Fears Jr., who leads the nation with 9.4 assists per game, and Jaxon Kohler, averaging 9.9 rebounds. Michigan State has improved significantly this season, moving from No. 21 to No. 8 in the coaches' poll, thanks to their physicality and strong rebounding. The game will be held at the Breslin Center in East Lansing, with a noon ET tip-off broadcast on Fox. Predictions favor Michigan State, citing their defensive strength and home-court advantage, with a close score expected, such as MSU 67, Duke 65. The matchup is part of a weekend full of ranked college basketball games, including key contests involving Kentucky, Purdue, Arizona, and others, with implications for NCAA tournament seeding and national championship contenders.